Altered GABAA,slow Inhibition and Network Oscillations in Mice Lacking the GABAA Receptor β3 Subunit
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منابع مشابه
Altered GABAA,slow Inhibition and Network Oscillations in Mice Lacking the GABAA Receptor 3 Subunit
Harald Hentschke, Claudia Benkwitz, Matthew I. Banks, Mark G. Perkins, Gregg E. Homanics, and Robert A. Pearce Department of Anesthesiology, University of Wisconsin, Madison, Wisconsin; Section of Experimental Anesthesiology, Department of Anesthesiology, Eberhard-Karls-University, Tuebingen, Germany; and Departments of Anesthesiology and Pharmacology, University of Pittsburgh School of Medicin...
متن کاملAltered GABAA,slow inhibition and network oscillations in mice lacking the GABAA receptor beta3 subunit.
Phasic GABAergic inhibition in hippocampus and neocortex falls into two kinetically distinct categories, GABA(A,fast) and GABA(A,slow). In hippocampal area CA1, GABA(A,fast) is generally believed to underlie gamma oscillations, whereas the contribution of GABA(A,slow) to hippocampal rhythms has been speculative. Hypothesizing that GABA(A) receptors containing the beta(3) subunit contribute to G...
متن کاملAltered GABAA,slow inhibition and network oscillations in mice
1 GABAA receptor β3 subunit 2 3 4 Harald Hentschke, Claudia Benkwitz, Matthew I. Banks, Mark G. Perkins, Gregg E. 5 Homanics and Robert A. Pearce 6 7 1. Department of Anesthesiology, University of Wisconsin, Madison, WI 53706, USA 8 2. Section of Experimental Anesthesiology, Department of Anesthesiology, Eberhard9 Karls-University, Tuebingen, Germany 10 3. Departments of Anesthesiology and Phar...
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Igor Spigelman, Zhiwei Li, Jing Liang, Elisabetta Cagetti, Sepideh Samzadeh, Robert M. Mihalek, Gregg E. Homanics, and Richard W. Olsen Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, California 90095; Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095; and Department of Anesthesiology/Critical Care Medicine, Un...
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The alpha5 subunit of the GABA(A) receptor is localized mainly to the hippocampus of the mammalian brain. The significance of this rather distinct localization and the function of alpha5-containing GABA(A) receptors has been explored by targeted disruption of the alpha5 gene in mice. The alpha5 -/- mice showed a significantly improved performance in a water maze model of spatial learning, where...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2009
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00651.2009